Dynamic Susceptibility Contrast Imaging Using a Multi-Echo Spiral Sequence

Nicolas Pannetier^1,2, Thomas Christen^1,2, Mohamed Tachrount^1,2, Benjamin Lemasson^1,3, Regine Farion^1,2, Sebastien Reyt^1,2, Nicolas Coquery¹, Christoph Segebarth^1,2, Chantal Remy^1,2, Emmanuel Louis Barbier^1,2

To characterize microvasculature, one can perform a DCE-MRI followed by a DSC-MRI experiment. However, estimates from a DSC experiment performed after a DCE-MRI experiment differ from estimates derived from a single DSC experiment, especially due to different T1. In this study, we investigate how T1 effect contributes to rCBV estimates in the case of one and two consecutive injections of contrast agent (CA). Thus, we used a multi echo spiral sequence in a rat glioma model. Results suggest that DSC-MRI performed during a second injection of CA is less sensitive to T1 effects than DSC-MRI performed during a first injection.