Quantitative Mouse Renal Perfusion Imaging Using Arterial Spin Labeling

Reshmi Rajendran¹, Cai-Xian Yong¹, Jolena Tan¹, Jiongjiong Wang², Kai-Hsiang Chaung¹

Synopsis We demonstrated quantitative renal perfusion in mice using ASL MRI. Perfusion was measured using a FAIR spin-echo EPI. Respiratory motion, susceptibility and fat artifacts were controlled by triggering, high-order shimming, and water excitation, respectively. High perfusion signal was obtained in the cortex compared to the medulla and signal was absent in scans carried out post mortem. Change in the cortical perfusion was observed after manipulating gas compositions including 5% CO2.