Yuguang Meng1,
Seong-Gi Kim1,2
1Department of Radiology, University of
Pittsburgh, Pittsburgh, PA, United States; 2Department of
Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States
The
blood transit time from arterial spin labeling plane to capillaries in the
imaging slice (referred to as tissue transit time) decreased during
neuronal activation in humans, while it appeared no changes during
somatosensory stimulation in rats. Since a tissue transit time is shorter in
rats compared to humans, shortening blood transit time may not be detectable
with arterial spin labeling (ASL) data with low temporal resolution. Thus, it
is important to carefully measure dynamic transit time changes during
stimulation. In this work, the dynamics of both CBF and the blood transit
time during rat forepaw stimulation were simultaneously measured with a
modified dynamic ASL (DASL) method with improved temporal resolution.