Pushing Transfer Insensitive Labeling Technique (TILT) from Pulsed Arterial Spin Labeling to Pulsed-Continuous Arterial Spin Labeling

Cheng Ouyang¹, Bradley P. Sutton^1,2

Transfer Insensitive Labeling Technique (TILT) has been used to measure cerebral blood flow as a pulsed arterial spin labeling (PASL) method. With the MT-insensitive feature, we propose to convert the original TILT to be further developed into a novel non-flow-driven pulsed-continuous ASL technique, named pulsed-continuous TILT (pTILT), with higher signal and fewer artifacts. Simulation show comparable labeling efficiency of pTILT compared to the current pulsed-continuous flow-driven adiabatic labeling techniques. In vivo human perfusion measurements by pTILT agree with literature