Evaluation of Anti-Angiogenic Effects of a New Synthetic Candidate Drug KR-31831 on Xenografted Ovarian Carcinoma Using Dynamic Contrast-Enhanced MRI

Jehoon Yang¹, Geun-Ho Im², Jae-Hun Kim¹, Hyejung Heo², Sera Yoon², Eunhee Cho², Jaewon Lee², Jung Hee Lee¹

Converging evidences have indicated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides parameters indicating permeability of tumor microvessels which has been shown to be closely related to angiogenesis. Because endothelial cells are thought to be genetically stable compared with tumor cells, tumor vasculature can be one of promising target for novel anticancer agents. Therefore we designed this study to investigate the anti-angiogenic inhibitory effect of KR-31831 that was newly developed for anti-ischemic agent by our co-worker group on xenografted human ovarian carcinoma model using DCE-MRI on a micro 7.0 Tesla MR system. Our preliminary results suggest DEC-MRI may be useful tools to evaluate the anti-angiogenic effect of KR-31831 on xenografted human ovarian carcinoma model.