Abstract #1720

Accuracy of T1-Fitting for Pharmacokinetic Analysis of Dynamic Contrast-Enhanced MRI

Paul Wessel de Bruin¹, Maarten J. Versluis¹, Erlangga Yusuf², Monique Reijnierse¹, Iain Watt¹, Matthias J P van Osch¹

¹Radiology Department, Leiden University Medical Center, Leiden, Netherlands; ²Rheumatology Department, Leiden University Medical Center, Leiden, Netherlands

The accuracy of Arterial Input Function and tissue response curve calculation in Dynamic Contrast-Enhanced MRI and Pharmacokinetic Analysis can be improved by calculating T1-maps after contrast administration and dynamic acquisition. The resulting T1-fits have lower standard deviation and a higher signal-to-noise ratio which translates linearly to improved concentration curve estimation.