Ashley D. Harris1,2, Linda B. Andersen,
2,3, Henry Chen, 2,4, Pranshu Sharma2, Richard
Frayne, 2,3
1School of Psychology, CUBRIC, Cardiff
University, Cardiff, United Kingdom; 2Seaman Family MR Research
Centre, Foothills Medical Centre, Calgary, Alberta, Canada; 3Clinical
Neurosciences and Radiology, Univerisity of Calgary, Calgary, Alberta,
Canada; 4Physics, Univerisity of Calgary, Calgary, Alberta, Canada
The
evolution of FA is examined in a canine model following blood brain barrier
disruption with hypertonic mannitol solution. White matter and grey matter
show different FA responses to blood brain barrier disruption. White matter
decreases, while grey matter showed significant increases. With additional
understanding, FA may assist in determining the integrity of the blood brain
barrier.