Yajing Zhang1,
Kenichi Oishi2, Michael I. Miller3, Jiangyang Zhang4,
Susumu Mori2,5
1Biomedical Engineering, Johns Hopkins
University School of Medicine, Baltimore, MD, United States; 2Radiology
and Radiological Science, Johns Hopkins University School of Medicine,
Baltimore, MD, United States; 3Center for Imaging Science, Johns
Hopkins University, Baltimore, MD, United States; 4Radiology and
Radiological Science, , Johns Hopkins University School of Medicine,
Baltimore, MD, United States; 5F.M.Kirby Resarch Center for
Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United
States
We
performed comprehensive studies of human white matter anatomy using a novel
atlas based automated fiber tracking system. 130 3-D ROIs were transformed
from our brain atlas to the individual subject using non-linear
transformations and used for automated fiber tracking. This approach allows
exhaustive search of white matter bundles that consistently exist in the
normal population. The method was validated by comparing to manual results by
experts. We identified 29 short cortico-cortical association fibers in
addition to well-defined major bundles. Probabilistic maps of such tracts in
normalized space were constructed for the first time in the normal
population.