Laura-Adela
Harsan1, Csaba David2, Marco Reisert1, Susanne
Schnell1, Jrgen Hennig1, Dominik von Elverfeldt1,
Jochen F. Staiger2
1Department of Diagnostic Radiology,
Medical Physics, University Hospital, Freiburg, Germany; 2Department
of Neuroanatomy, Institute for Anatomy and Cell Biology, Freiburg, Germany
The
present study validates an in-vivo DT-MRI and FT protocol capable of
identifying and characterizing the subtle connection pathways in the living
mouse brain. The reconstructions of the thalamocortical projections derived
from in-vivo DT-MRI were co-registered and correlated with 3D reconstructions
of the fibers labeled with Phaseolus vulgaris-leucoagglutinin histological
tracer, injected in the thalamus of the same animal. Good agreement between
the deterministic and probabilistic tractography and the histological tracing
was obtained in wild type and reeler mutant brains