Tzu-chen Yeh1, Chou-Ming Cheng1,
Zong-Kai Hsu2, Jen-Chuen Hsieh2, Low-Ton Ho1
1Department of Medical Research and
Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan; 2Institute
of Brain Science, National Yang-Ming University, Taipei, Taiwan, Taiwan
The
spatial template of default-mode network (DMN) of sixty normal subjects has
been constructed as five regions of interest (ROIs) as precuneus/posterior
cingulate areas with the highest reproducibility. Multimodal approaches using
BOLD-based fMRI and probabilistic DTI (pDTI) demonstrated the limited
structural connectivity within each ROI within DMN correlates. By penetration
maps of pDTI in twenty-two normal subjects, asymmetry of bilateral cingulum
cortices implied preference of right posterior medial parietal regions for
interpretation of internal/external environment with concert action of medial
prefrontal areas, as one of the potential functions of DMN.