Monica Bucci1, Maria Luisa Mandelli2,
Jeffrey I. Berman, Bagrat Amirbekian3,4, Christopher Nguyen,
Mitchel S. Berger5, Roland G. Henry
1Radiology and Biomedical Imaging,
University of California San Francisco, San Francisco, CA, United States; 2Department
of Neuroradiology, Istituto Neurologico Carlo Besta, Milano, Italy; 3Radiology
and Biomedical Imaging, University of California, San Francisco; 4UC
Berkeley and UCSF Graduate Program in Bioengineering; 5Department
of Neurological Surgery, University of California San Francisco
There
are different methods available for fiber tracking but only with few methods
it is possible to quantify the accuracy and precision in clinical
applications. We used preoperative HARDI data from patients with cerebral
glioma to obtain corticospinal fiber tracts with deterministic and
probabilistic Diffusion Tensor and Q-Ball fiber tracking algorithms using
cortical and subcortical stimulation sites from IES as gold standard. The
functional motor sites allows determination of the false negative rate of
connectivity, which reflects the accuracy of the tractograms. The subcortical
stimulation sites enable determination of the accuracy and precision of the
course of the predicted CST.