Eleftheria Panagiotaki1, Matt G. Hall1,
Bernard Siow1,2, Mark F. Lythgoe2, Daniel C. Alexander1
1Centre for Medical Image Computing,
Dept. of Computer Science, University College London, London, United Kingdom;
2Centre for Advanced Biomedical Imaging, University College
London, London, United Kingdom
This
work outlines a method to construct detailed three-dimensional geometric
models of tissue microstructure using confocal laser scanning microscopy
(CLSM) images. We use these models to simulate the diffusion MRI signal from
the tissue by running random-walk simulations within the resulting mesh. The
precise simulated data from our method provide a mechanism for evaluating the
quality of simple parametric models and the parameter estimates they provide.