Abstract #1437

Realtime Cine MRI in Mice with a Single-Shot EPI Sequence and the KarhunenLoeve Transform

Guangping Dai¹, Yu Ding², Shuning Huang¹, Orlando P. Simonetti², David E. Sosnovik³

¹Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School; ²Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University; ³Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Realtime cine MRI of the mouse heart is reported using a single-shot EPI sequence and the KarhunenLoeve transform. The entire mouse heart can be imaged with this technique in less than 5 minutes, using minimal sedation. This report demonstrates the ability of MRI to be used for high-throughput applications, and compete with echocardiography, in the basic science as well as and clinical settings.