Zhuoli Zhang1, Shengyong Wu2,
Ying Liu3, Savita Puri4, Shara Ramaswamy5,
Yi Huan3, Debiao Li1
1Northwestern University, Chicago, IL,
United States; 2Tianjin Medical University; 3Fourth
Military Medical University; 4University of Rochester Medical
Center; 5Florida International University
Phosphorus-31
magnetic resonance spectroscopy (31P-MRS) represents a unique instrument to
noninvasively monitor myocardial metabolism in humans. The technique has been
used to study the metabolism in myocardium in patients with coronary artery
disease (CAD). The measurements permit
quantitative estimation of the phosphocreatine (PCr)/adenosine triphosphate
(-ATP) ratio which reflects the energetic state of the myocardium. Previous
studies investigated the effect of successful coronary artery bypass grafting
surgery (CABG) upon left ventricular function. Although residual myocardial
viability in patients with CAD and extensive regional asynergy is associated
with improved ventricular function after CABG, the relationship between
myocardial metabolism and heart function after CABG remains unclear. We
hypothesized that cardiac function benefits from high-energy phosphate (HEP)
and sought to investigate the relationship between HEP and cardiac function
in CAD patients using cine magnetic resonance imaging (cine-MRI) and 31P-MRS.