Albrecht
Stroh1, Florian Schmid2, Afra Wohlschlaeger3,
Valentin Riedl4, Jenny Kressel3, Cornelius Faber2
1Department of Neuroradiology,
Technical University Munich, Munich, Germany; 2Institute for Clinical
Radiology, University Hospital Mnster, Mnster, Germany; 3Department
of Neuroradiology, Technical University Munich, Germany; 4Department
of Neurology, Technical University Munich, Germany
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this study we tested the feasibility of rat fMRI at highest field strength in
combination with an implanted optical fiber. We aim for the combination of
fiber based optical Ca2+ imaging with functional magnetic resonance imaging
(fMRI) at 17.6 T in vivo. We increased the temporal resolution of fMRI to 20
ms by applying k-space segmentation. Additionally, we conducted fiber-based
Ca2+ imaging in mice upon electric forepaw stimulation, detecting neuronal
population activity. Our study indicates that a multimodal approach combining
a global method like fMRI with a spatially confined, highly specific method
as optical Ca2+ imaging becomes amenable.