Characterization and Correction of Physiological Instabilities in 3D FMRI

Rob Hendrikus Tijssen¹, Steve M. Smith¹, Peter Jezzard¹, Robert Frost¹, Mark Jenkinson¹, Karla Loreen Miller¹

3D FMRI acquisitions have the advantage of allowing high resolution, isotropic, imaging. However, 3D acquisitions, such as SSFP and SPGR, show increased signal instabilities in the inferior regions of the brain. Here, we present a characterization of these temporal instabilities and propose a GRAPPA-based correction method that allows retrospective gating of 3D FMRI data.