Matthew Borzage1,2, Marvin Nelson3,
Istvan Seri1,4, Stefan Blml3,5
1Neonatal Medicine, Childrens Hospital
Los Angeles, Los Angeles, CA, United States; 2Viterbi School of
Engineering, University of Southern California, Los Angeles, 90007, United
States; 3Department of Radiology, Childrens Hospital Los Angeles,
Los Angeles, CA, United States; 4Keck School of Medicine,
University of Southern California, Los Angeles, CA, United States; 5Rudi
Schulte Research Institute, Santa Barbara, CA, United States
Studying
changes in cerebral hemodynamics is possible via MR, including blood oxygen
level dependent (BOLD) imaging. We
used near infrared spectroscopy (NIRS) to sample oxy- and deoxyhemoglobin
directly, and utilized a nitrogen challenge to change FiO2 and thus cause
measurable changes in blood oxygenation.
We have observed good correlation between the BOLD and NIRS signals,
with higher correlation in the gray matter than in the white matter. In the
near future, we will use this paradigm to study the limited autoregulation of
cerebral blood flow in preterm neonates.