Miriam Scadeng1, Ellen Breen2,
Nathan Gray1, David Dubowitz1
1Radiology, UC San Diego, San Diego,
CA, United States; 2Medicine, UC San Diego, San Diego, CA, United
States
Being
a relatively new animal model there is no comprehensive 3D anatomical atlas
onto which temporal or spatial data can be projected. In addition, methods
for in-vivo imaging of adult fish are needed if zebrafish researchers are to
benefit from functional MR imaging techniques such as MRS, MEMRI, BOLD and
even ASL that are routinely being used in mouse models of disease. The major
challenges include the very small size of the fish, and imaging the live fish
in water. We present methods for in-vivo MRI of zebrafish, and a 3D atlas of
zebrafish anatomy.