Aaron Keith Grant1, Elena Vinogradov1,
Pankaj K. Seth1, Xiaoen Wang1, Robert E. Lenkinski1,
Vikas P. Sukhatme1
1Beth
Hyperpolarized
pyruvate undergoes rapid conversion into lactate, alanine, and bicarbonate in
vivo. Lactate is of particular
interest as elevated lactate levels may serve as a biomarker for cancer. Although lactate SNR has been shown to
correlate with histological characteristics of tumors, quantitative measures
of kinetics are desirable. We present
fits of a simple two-site exchange model to data acquired in an animal model
of non-small lung cancer, and show that these methods can quantify reductions
in lactate formation rates following administration of dichloroacetate, a
drug that up-regulates the activity of pyruvate dehydrogenase.