Shingo Matsumoto1, Doug Morris2,
Martin Lizak2, Jeeva P. Munasinghe2, Keita Saito1,
Jan Henrik Ardenkjaer-Larsen3, Sankaran Subramanian1,
Nallathamby Devasahayam1, Kevin Camphausen1, Alan
Koretsky2, James B. Mitchell1, Murali C. Krishna1
1National Cancer Institute, Bethesda,
MD, United States; 2National Institute of Neurological Disorder
and Stroke, Bethesda, MD, United States; 3GE Healthcare, Amersham,
United Kingdom
Many
tumor types can undergo aerobic glycolysis, where tumors can abnormally
obtain as much as 50% of their energy (ATP) by metabolizing sugar glucose
directly to lactate even in the presence of oxygen. Likewise, approximately
one half of tumors exhibit marked hypoxia. Collectively, these traits can
contribute to resistance to cancer treatments. Non-invasive assessment of
altered tumor metabolism and tissue hypoxia might be useful for both
diagnostic and treatment strategies. In this study EPR oxygen imaging and
hyperpolarized MRI of 13C-labeled pyruvic acid, are coupled to
provide a measure of tumor hypoxia and energy metabolism.