Muhammed Yildirim1,2, Shelton D. Caruthers3,
Aart J. Nederveen4, Jaap Stoker4, Rolf Lamerichs1
1Philips Research, Eindhoven,
Netherlands; 2Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 3Washington
University, St Louis, MO, United States; 4Department of Radiology,
Academic Medical Center, Amsterdam, Netherlands
In vivo 3D F-uTSI, can distinguish
various 19F compounds based on chemical shift differences allowing for
multicolor imaging, without additional increase in scan time. 3D F-uTSI is
an efficient spectral imaging technique; data with a resolution of 48x48x14
can be recorded with a scan-time of 6:23m. The spectra of several Perfluorocarbon
emulsion can be uniquely identified from these data. Main advantage of the
spectroscopic, multicolor, imaging approach is that the spectral images of
the different PFC agents are recorded at the same time and, furthermore,
complex biological process can be imaged using co-injection of differently
functionalized PFC emulsions.