Aiming Lu1, Ian C. Atkinson1,
Xiaohong Joe Zhou1,2, Keith R. Thulborn1
1Center for MR Research, University of
Illinois at Chicago, Chicago, IL, United States; 2Departments of
Neurosurgery, Radiology, and Bioengineering, University of Illinois at
Chicago, Chicago, IL, United States
Phosphocreatine
(PCr) concentration can provide vital bioenergetic information in brain. Due
to their low detection sensitivity, 31P MR signals are often detected with
MRS or CSI approaches, which are either time consuming or spatial resolution
limited. In this work, we report initial 31P imaging results using a spectral
selective twisted projection imaging (TPI) sequence to achieve high data
acquisition efficiency on a 9.4T human scanner. PCr and γ-ATP images
were simultaneously obtained with whole brain coverage and reasonable SNR,
temporal and spatial resolution. The ratio of the two resonances images can
potentially allow detection of variation in PCr concentration.