Federico
Giove1,2, Francesco Marcocci1, Fabrizio Fasano,
1,3, Mauro DiNuzzo1, Gisela E. Hagberg3, Bruno
Maraviglia1,2
1Department of Physics, Sapienza
University of Rome, Rome, RM, Italy; 2MARBILab, Enrico Fermi
Center, Rome, RM, Italy; 3Neuroimaging Laboratory, Fondazione
Santa Lucia IRCCS, Rome, RM, Italy
We
developed an outer volume suppression approach for nulling the external
signal in single voxel spectroscopy, based on trains of adiabatitic skewed
selective pulse. The pulses shape allowed the saturation bands to be
prescribed adjacent to the voxel, without loss of signal. The train was
tested before STEAM and PRESS acquisition schemes at 3T, and showed excellent
performaces both in vitro and in vivo, in particolar for the suppression of
exravoxel lipids in the visual cortex. Optimal performances were observed
with VAPOR water suppression and short TE STEAM, but the approach worked
eqaully well before PRESS at intermediate (30ms) TE