Congju Chen1, David J. Brenner2,
Truman R. Brown1
1Department of Radiology, Columbia
University, New York, NY, United States; 2Center for Radiological
Research, Columbia University, New York, NY, United States
In
previous work we have identified a dozen biomarkers in urine from
radiation-exposed mice by NMR spectroscopy. The mouse model allowed us to
understand the effect of key parameters such as dose, time post-exposure on
the urinary biomarkers. To validate these biomarkers in humans, in this work
we investigate urinary biomarkers associated with radiation exposure in acute
leukemia patients undergoing a series of total body irradiation treatments in
preparation for a hematopoietic stem cell transplant. The results indicated
that besides some common urinary radiation biomarkers from both mice and
human, there are some unique radiation signatures in human urine.