Lionel Marc Broche1, Saadiya Rashid Ismail1,
Nuala A. Booth2, David J. Lurie1
1Aberdeen Biomedical Imaging Centre,
University of Aberdeen, Aberdeen, Scotland, United Kingdom; 2Institute
of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, United
Kingdom
In
this work we examine the feasibility of measuring the content of fibrin
clots, which is the protein network that stabilises a thrombus, using fast
field-cycling NMR. Fibrin, like proteins in general, is rich in 14N
and its mobility is reduced due to the web-like structure of a clot. These
two conditions are the cause of the apparition of a specific signal in the 1H
dispersion plot, called the quadrupole signal, which can be used to measure
the fibrin content.