Ivan Dimitrov1, Deborah Douglas2,
Jimin Ren2, Andrew G. Webb3, A Dean Sherry2,
Craig R. Malloy2
1Philips Medical Systems, Cleveland,
OH, United States; 2Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, TX, United States; 3Radiology,
Leiden University Medical Center, Leiden, Netherlands
The
role of diet and fat consumption in the pathogenesis of breast cancer is an
important subject. We report on the non-invasive determination of lipid
composition in human breast by 1H-MRS at 7T. Two
respiratory-triggered TE-averaged STEAMs were performed in healthy volunteers
where the second acquisition had all gradients inverted. T1 and T2
were also measured. Ten lipid peaks were typically resolved. The average lipid composition was 30.5%
saturated, 48.4% mono-unsaturated, and 21.1% di-unsaturated. In conclusion,
we have shown that a chemical analysis of lipids in breast tissue can be
determined quite simply and non-invasively by proton MRS at 7T.