Laura Mancini1,2, Rathie Rajendram3,
Jimmy Uddin3, Richard W J Lee4, Geoffrey E. Rose3,
Tarek Yousry1,2, Katherine Miszkiel1,3, John S.
Thornton1,2
1Lysholm Dept Neuro-radiology, National
Hospital for Neurology and Neurosurgery, Univ College London Hospitals NHS
Foundation Trust, London, United Kingdom; 2Academic
Neuroradiological Unit, Institute of Neurology, University College of London,
London, United Kingdom; 3Moorfields Eye Hospital NHS Foundation
Trust, London, United Kingdom; 4Academic Unit of Ophthalmology,
Clinical Science at South Bristol, University of Bristol, Bristol, United
Kingdom
This
study shows that there is correlation between T2 relaxation values in the
extra-orbital muscles of patients with thyroid eye disease and Clinical
Activity Score (CAS). CAS is the gold-standard measure of disease activity,
considered to reflect the degree of orbital inflammation, while T2-weighted
images are sensitive to changes in tissue water content concomitant with
extra-orbital muscle inflammation. This study represents a validation of T2
measurements as outcome measures for studies of interventions in TED. T2
measures have therefore the potential to improve the quality of data reported
in Randomised Control Trials.