Rajat
Gupta1, Uma Sharma2, Nandita Gupta1, U Singh3,
Randeep Guleria4, Naranamangalam R. Jagannathan2, Ravinder
Goswami1
1Department of Endocrinology, All India Institute of
Medical Sciences, New Delhi, Delhi, India; 2Department of NMR
& MRI Facility, All India Institute of Medical Sciences, New Delhi,
Delhi, India; 35Department of Physical Medicine and Rehabilitation,
All India Institute of Medical Sciences, New Delhi, Delhi, India; 4Department
of Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India
Effects
of six months cholecalciferol and calcium supplementation was investigated on
the skeletal muscle strength and muscle energy metabolism using 31PMRS in
healthy volunteers with low serum 25(OH)D in a double blind randomized
placebo controlled trial. At six months, 25(OH)D levels, hand grip strength, gastrosoleus muscle
strength, distance covered during six minute walk were significantly higher
in cholecalciferol compared to placebo group (p=0.001). There were no
significant differences in MIP, MEP and PCr/Pi ratio in the two groups at six
months. Thus, improvement in muscle strength could be due to factors other
than change in muscle energy metabolism.