Albrecht Ingo Schmid1,2, Martin Andreas3,
Martin Meyerspeer2,4, Ewald Moser1,4, Michael Wolzt1
1Dpt. of Clinical Pharmacology, Medical
University of Vienna, Wien, Austria; 2MR Center of Excellence,
Medical University of Vienna, Wien, Austria; 3Department of
Cardiac Surgery, Medical University of Vienna, Wien, Austria; 4Center
of Biomedical Engineering and Physics, Medical University of Vienna, Wien,
Austria
Post-ischemic
stenosis is a common clinical finding, yet rarely studied by NMR. 31P MRS and
BOLD sensitive EPI was measured (two days) in 11 male subjects, with and
without 5min stenosis (cuff at 30mmHg below cystolic pressure) following
20min cuff (thigh), the last two minutes performing plantar flexion. During
stenosis pH and PCr remained at post-ischemic levels, BOLD signal declined
further. In conclusion, stenosis is a state in which oxygen supply is
insufficient to start PCr recovery.