Gil Navon1, Uzi Eliav1
1School of Chemistry,
The
analysis of the magnetization transfer contrast under incomplete saturation
of the macromolecules (common in clinical setups) requires the knowledge of
the macromolecular spectral lineshape. In previous studies this information
was retrieved by fitting the MTC data to models where the lineshape
characteristic was kept as a free parameter. In the current study we present
a method that is a combination of double and zero quantum filtering for
measuring the macromolecular lineshape.
A demonstration of the method is given for the macromolecular fraction
of articular cartilage. The lineshape is Gaussian with width at half height
of 27.3 kHz.