Haihui Cao1,2, Jerome L. Ackerman, 2,3,
Guangping Dai, 2,3, Mirko Hrovat4, Melvin J. Glimcher,
2,5, Yaotang Wu, 2,5
1Department of Orthopedic Surgery,
Children's Hospital , Boston, MA, United States; 2Harvard Medical
School, Boston, MA, United States; 3Department of Radiology,
Massachusetts General Hospital, Boston, MA, United States; 4Mirtech,
Inc, Brockton, MA, United States; 5Department of Orthopedic
Surgery, Children's Hospital, Boston, MA, United States
Questions
have arisen as to the nature of the molecular species giving rise to the
short-T2 proton signal in Water- and fat-suppressed proton projection MRI
(WASPI), a noninvasive means to image bone.
In this study we use deuterium exchange to identify the source of
proton signal in WASPI.