May Abdel Hamid Taha1, Sarah L. Manske2,
Erika Kristensen3, Jaymi T. Taiani4, Roman Krawetz5,
Ying Wu, Steven K. Boyd6, John Robert Matyas7, Derrick
E. Rancourt5, Jeffery F. Dunn1
1Radiology, University of Calgary,
Calgary, Alberta, Canada; 2Kinesiology; 3Mechanical and
Manufacturing Engineering; 4
Medical Sciences; 5Departments of Oncology, Biochemistry &
Molecular Biology and Medical Genetics; 6Mechanical and
Manufacturing Engineering; 7Comparative Biology and Experimental
Medicine in Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
The
objective of this study was to investigate the effect of different
biomaterials on bone healing in vivo in a mouse model of bone injury. These
materials; matrigel, purecol gel and hydroxyapatite (HA) are potential
matrices to support stem cells. Optimized in vivo MR microscopy and micro
computed tomography were used to assess fracture repair. In addition, MRI
images and CT scans were compared at the same time point, to show the
difference between them in revealing the actual stage of healing.