Victor Rakesh Lazar1, Gary P. Liney2,
David J. Manton1, Peter Gibbs1, Martin Lowry1,
Celia L. Gregson3, Joern Rittweger4, Sue Steel5,
Chris Langton6, J H. Tobias3, Lindsay W. Turnbull1
1Centre for MR Investigations,
University of Hull, Hull, North Humberside, United Kingdom; 2Radiotherapy
Physics, University of Hull, Hull, North Humberside, United Kingdom; 3Academic
Rheumatology, University of Bristol, Bristol, United Kingdom; 4Excercise
and Sports Medicine, Manchester Metropolitan University, Manchester, United
Kingdom; 5Centre for Metabolic Bone Disease, Hull Royal Infirmary,
Hull, North Humberside, United Kingdom; 6School of Physical and
Chemical Sciences, Queensland University of Technology, Australia
Bone
quantification is commonly measured using DEXA and pQCT. Research in MRI and
MRS have shown promising potential in the quantification of bones. Our work
was based on using these ideas in a clinical setting on individual patients.
The work was involved in a High Bone Mass (HBM) study program to identify
individuals affected with a genetic condition of LRP5. pQCT data was
collected from 169 individuals from the HBM study. 43 people were selected
for MRI and MRS acquisition from the total pQCT population. Preliminary
results from these investigations have been explained in this abstract.