Henry Rusinek1, Lidia Glodzik2,
Miroslaw Brys3, Francois Haas4, Kellyanne Mcgorty1,
Qun Chen1, Mony J. de Leon2
1Radiology, New York University School
of Medicine, New York, NY, United States; 2Psychiatry, New York University
School of Medicine, New York, NY, United States; 3Neurology, New
York University School of Medicine, New York, NY, United States; 4Medicine,
New York University School of Medicine, New York, NY, United States
Hippocampal
blood flow and vascular reactivity were measured in 34 normal subjects aged
26-92 years using pulsed ASL with segmented TrueTFISP readout. Test-retest
studies indicate reproducibility averaging 3.6 ml/100g/min (5.4%).
Hippocampal flow averaged 61.29.0 ml/100g min, with no age effect. The
cortical flow averaged 57.210.4 ml/100g min and there was a significant
linear relationship with age. Mild hypercapnia resulted in a significant CBF
increase in all brain tissue. The flow response was 18.012.2 in neocortex
and 14.110.8 in the hippocampus. The cortical flow response among the women
was significantly larger than in men, confirming numerous prior studies.