Yen-Yu Ian Shih1,2, Yun-Chen Chiang2,3,
Yi-Hua Hsu2, Fu-Shan Jaw3, Jin-Chung Chen4, Bai-Chuang
Shyu2, Timothy Q. Duong1, Chen Chang2
1Research Imaging Institute, University
of Texas Health Science Center at San Antonio, San Antonio, TX, United
States; 2Functional and Micro-Magnetic Resonance Imaging Center, Academia
Sinica, Taipei, Taiwan; 3Institute of Biomedical Engineering,
National Taiwan University, Taipei, Taiwan; 4Department of
Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan
Dopamine
and opioids have been implicated in various aspects of brain signaling. By
employing CBV-weighted fMRI with pharmacological treatments, the present
study reveals that endogenous stimulation of ?opioid receptors underlies
negative CBV fMRI signals via the activation of dopamine D2/D3 receptors. The
interpretation of fMRI data involving opioiddopamine interactions requires
careful consideration.