1Hospital for Sick Children, Toronto, ON,
Canada
Comprehensive
phenotyping of large numbers of mutant mice is laborious and expensive.
Three-dimensional imaging is a promising approach for providing overviews of
anatomical and functional phenotypes. This talk will describe some of the
developments in high throughput imaging methods such as MR, X-ray CT, and
optical imaging. Equally, or even more importantly, quantitative computer
methods for analyzing differences in the 3D sets will be described. Example
applications to a variety of mutants will be shown. Particular emphasis will
be given to imaging of embryonic mutations given the expected large numbers
of embryonic lethals from the single gene knockout programs.
