Abstract #0680

Non-Invasive and Temporally Resolved Measurement of Ischaemic Tissue Damage in Acute Stroke Using Quantitative 23Na Magnetic Resonance Microscopy at 7 T

Friedrich Wetterling¹, Lindsay Gallagher², Mhairi I. Macrae³, Sven Junge⁴, Andrew John Fagan⁵

¹School of Physics, Trinity College Dublin, Dublin, Ireland; ²Glasgow Experimental MRI Centre, , Division of Clinical Neuroscience, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom; ³Glasgow Experimental MRI Centre, Division of Clinical Neuroscience, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom; ⁴Bruker BioSpin GmbH, Ettlingen, Germany; ⁵Centre for Advanced Medical Imaging, St. Jamess Hospital, Dublin, Ireland

In the current study, quantitative ²³Na Magnetic Resonance Microscopy (qNa MRM) was used to measure the time course of Tissue Sodium Concentration (TSC) in order to investigate regional variations in TSC behavior in the first 8 hours after stroke in a rodent model. The timecourse of the TSC evolution was reproducible (n=5) with similar regional delays evident in the timepoint at which the TSC increased during the first hours after MCAO in each rat. The delay time parameter could be used as a measure of ischaemic core tissue growth, non-invasively and temporally resolved, thereby offering an alternative method to post-mortem histology.