Jessy J. Mouannes1, Wanyong Shin2,
Saurabh Shah3, Anindya Sen4, Sameer Maheshwari1,
Timothy J. Carroll1,4
1Biomedical Engineering, Northwestern
University, Chicago, IL, United States; 2National Institute on
Drug Abuse, National Institute of Health, Baltimore, MD, United States; 3Siemens
Medical Solutions USA, Chicago, IL, United States; 4Radiology,
Northwestern University, Chicago, IL, United States
The
multi-scan Bookend technique allows accurate, reliable and reproducible
quantitative cerebreal perfusion measurements. An accelerated and simplified
version of the Bookend technique protocol has been achieved through a
Self-CALibrated Epi Perfusion Weighted Imaging (SCALE-PWI) MRI pulse
sequence, with scan time under 2 minutes and allowing inline reconstruction
of quantitative images of cerebral perfusion.
A study of two different delay times between consecutive modules of
SCALE-PWI and a water correction factor (WCF) parameterization for SCALE-PWI
are presented at 1.5T. The results show that a fast imaging protocol for
SCALE-PWI (with zero delay) with appropriate WCF parameterization provide
accurate quantitative cerebral perfusion.