Rishi Awasthi1, Nuzhat Husain2,
Priyanka Soni2, Prativa Sahoo3, Sanjay Behari4,
Shaleen Kumar5, Rakesh Pandey6, Ram Kishore Singh
Rathore3, Rakesh Kumar Gupta1
1Radiodiagnosis, Sanjay Gandhi Post
Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Pathology,
Chhatrapati Shahuji Maharaj Medical University, Lucknow, UP, India, Lucknow,
Uttar Pradesh, India; 3Mathematics and Statistics, Indian
Institute of technology Kanpur, Kanpur, Uttar Pradesh, India; 4Neurosurgery,
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar
Pradesh, India; 5Radiotherapy, Sanjay Gandhi Post Graduate
Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 6Pathology,
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar
Pradesh, India
DCE-MRI
was performed on 17 patients with Glioblastoma multiforme (GBM). Various
perfusion metrics were analyzed and correlated with immunohistochemically
obtained MMP-9 expression. Among the perfusion metrics, Kep was found to have
the best correlation with MMP-9 expression suggesting that it can be used as
a surrogate for MMP-9 expression. A total of 8 patients were also followed up
clinically to observe the duration of survival. The MMP-9 expression and
quantified perfusion metrics were also correlated with the duration of
survival. MMP-9 expression showed a significant negative correlation with the
duration of survival indicating the possible role of MMP-9 in tumor
progression as one of the factors. The Kep, Ktrans, Ve, rCBV and rCBF also
correlated significantly with the duration of survival proving the utility of
DCE MRI in forecasting tumor progression in malignant glioma. We suggest that
Kep holds promise as a surrogate for MMP9 expression in GBM.