Hao Huang1, Kirti Saxena2, Annie
Walley2, Min Xu1,
1Advanced Imaging Research Center,
University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department
of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX,
United States; 3Department of Radiology, University of Texas
Southwestern Medical Center, Dallas, TX, United States
Identifying
early signs of bipolar disorder is important because it may enable health
care providers to intervene earlier and prevent progression of increased
morbidity and personal dysfunction. Commissural tracts including corpus
callosum (CC) and anterior commissure (AC) are the research target in this
study. In our study, we acquired high resolution DTI from 10 pediatric
bipolar patients and 10 age matched control subjects. We found that AC and
anterior segment of CC has statistically smaller FA. Compared to DTI results
of adult BP, the disruption pattern caused by BP demonstrates anterior to
posterior pattern from childhood to adult.