Hamidreza Saligheh Rad1, James Love1,
Jeremy F. Magland1, Mary F. Leonard2, Felix W. Wehrli1
1Laboratory for Structural NMR Imaging,
Department of Radiology, University of Pennsylvania Health System,
Philadelphia, PA, United States; 2Nephrology, Children's Hospital
of Philadelphia, Philadelphia, PA, United States
Increased
porosity is a major cause of impaired strength of cortical bone. Ultra-short
TE MRI has been shown to be able to quantify bone water, which is either
collagen-bound or residing in the pores of the Haversian and
lacuno-canalicular system. In this preliminary work we compare bone water
concentration (BWC) in the tibial mid-shaft in a group of subjects with 3D
bone mineral density (BMD) at the same location as well as areal BMD at the
hip and spine. BWC is found to be inversely related to BMD at all sites and
increasing with age.