Sanna Gevers1, Matthias J.P. van Osch2,
Jeroen Hendrikse3, Reinoud P. Bokkers3, Dennis Kies2,
Wouter M. Teeuwisse2, Charles B.L.M. Majoie1, Aart J.
Nederveen4
1Radiology, Academic Medical Center
Amsterdam, Amsterdam, Netherlands; 2Radiology, Leiden University
Medical Center, Netherlands; 3Radiology, University Medical Center
Utrecht, Netherlands; 4Radiology, Academic Medical Center
Amsterdam, Netherlands
Thus
far, ASL variability studies have mainly focussed on intrasession and
intracenter and multicenter variability of global perfusion and of perfusion
in the flow territories of major brain feeding arteries. The purpose of this
study was to analyze variability patterns over different brain regions
performing a voxel based analysis of variance within and between imaging
sessions. The results of our study show that pseudo-continuous ASL with
background suppression is least variable over different brain regions whereas
other ASL techniques show more variability mainly in vascular regions. Most
striking per voxel variances were found in the posterior circulation for
pulsed ASL and in the frontal region for continuous ASL.