Christopher S. Eddleman1, Maulin Shah2,
Omar M. Arnaout1, Richard Bernstein3, Bernard R. Bendok1,
Hunt H. Batjer1, Timothy J. Carroll4
1Neurological Surgery, Northwestern
University, Chicago, IL, United States; 2Biomedical Engineering,
Pennsylvania State University, State College, PA, United States; 3Neurology,
Northwestern University, Chicago, IL, United States; 4Radiology,
Northwestern University, Chicago, IL, United States
Time-based
indicators of cerebral blood flow, e.g., Tmax and MTT, are often used to
grade stroke severity in both MR and CT perfusion studies. However, these
measures often overestimate the infarcted territory, thus underestimating
salvagable brain. We show that quantitative MR perfusion is superior to
time-based measures in distinguishing normally perfused from ischemic brain
tissue.