Sharon Giles1, Sophie F. Riches2,
Veronica A. Morgan1, Catherine Simpkin1, Nandita
deSouza2
1Cancer Research UK and EPSRC Cancer
Imaging Centre, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United
Kingdom; 2Cancer Research UK and EPSRC Cancer Imaging Centre,
Institute of Cancer Research & Royal Marsden NHS Foundation Trust,
Sutton, Surrey, United Kingdom
We
report T2, magnetisation transfer ratios, and apparent diffusion coefficients
for prostate tissues at 3T. ADC showed a lower coefficient of variation for
all prostate regions compared to other parameters, indicating it to be more
reliable at differentiating tumor from non-tumor in the prostate. Negative
correlation of ADC with MTR suggests that diffusion-weighted contrast may be
linked to features other than cellularity, with presence of large
macromolecules playing a role.