Daisuke Kokuryo1, Seiji Nakashima2,
Kai-Hsiang Chuang3, Iwao Kanno1, Kenji Kono2,
Ichio Aoki1
1Molecular Imaging Center, National
Institute of Radiological Sciences, Chiba, Japan; 2Graduate School
of Engineering, Osaka Prefecture University, Sakai, Osaka, Japan; 3Singapore
Bioimaging Consortium, Singapore, Singapore
A
multimodal thermo-sensitive polymer-modified liposome (MTPL) loaded with
anticancer drugs and contrast agents would be a powerful 'Theragnostic
(therapy + diagnosis)' tool. In this paper, drug concentration in deep-seated
tumor was evaluated using MTPL and a rapid quantitative imaging technique.
Heat-triggered drug-release from MTPL was visualized in combination with the
temperature distribution. MTPL concentration in the tumor area was maintained
for between 4 and 12 hours after administration. We concluded that to
minimize side-effects the optimum time to apply a heat-trigger is 12 - 24
hours after MTPL administration.