Abstract #0412

Ultra-High Field Measurements of Glycogen, IMCL and Perfusion in Skeletal Muscle in Post-Exercise Recovery: A 13C and 1H MRS Study

Mary Charlotte Stephenson¹, Frances Gunner², Elizabeth J. Simpson², Paul Greenhaff², Susan T. Francis¹, Ian A. MacDonald², Peter G. Morris¹

¹SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; ²School of Biomedical Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

This study assesses the feasibility of sequentially monitoring muscle glycogen and IMCL levels, and perfusion, in exercising and non-exercising thigh muscles, prior to and following exercise at 7T. Levels of glycogen in exercising muscles decreased significantly during exercise, with larger decreases following higher intensity exercise. Carbohydrate re-feeding increased glycogen levels with levels returning towards baseline. Levels of glycogen in the non-exercising muscles showed no change following exercise and re-feeding. No significant changes in IMCL were measured. Perfusion data indicates an increase in muscle perfusion during exercise, however further analysis will be carried out to further improve results.