Approaching Complete Separation of Benign and Malignant Breast Lesions by DCE-MRI: Impact on Healthcare Costs

Wei Huang¹, Patricia A. Carney¹, Luminita Alina Tudorica¹, Yiyi Chen¹, Xin Li¹, Elizabeth A. Morris², Ian J. Tagge¹, Sunitha Thakur², Maayan Korenblit², Jason A. Koutcher², Charles S. Springer¹

Shutter-Speed Model (SSM) analyses of breast DCE-MRI data from 98 suspicious lesions show significantly improved diagnostic accuracy compared to Standard Model (SM) analyses and clinical MRI protocols. The difference in Ktrans derived from the two models, Ktrans [ Ktrans(SSM) C Ktrans(SM)], has near perfect specificity at 100% sensitivity. The cost effectiveness of replacing unnecessary benign biopsies with SSM DCE-MRI is significant.