Pierre-Hugues Vivier1,2, Pippa Storey1,
Jeff L. Zhang1, Akira Yamamoto1, Kristopher Tantillo1,
Ruth P. Lim1, James S. Babb1, Henry Rusinek1,
Devon John3, Lewis W. Teperman3, Kent Friedman4,
Judith Benstein5, Edward Skolnik5, Vivian S. Lee1
1Radiology, NYU Langone Medical Center,
New York, New-York, United States; 2LITIS Laboratory EA4108,
School of Medicine and Pharmacy, Rouen, France; 3Transplant
Clinic, NYU Langone Medical Center, New York, New-York, United States; 4Nuclear
Medicine, NYU Langone Medical Center, New York, New-York, United States; 5Nephrology,
NYU Langone Medical Center, New York, New-York, United States
Glomerular
filtration rate (GFR) assessment based on creatinine formulas is highly
inaccurate in cirrhotic patients, despite its utmost importance. We
prospectively investigated the feasibility, accuracy, precision and
reproducibility of MR-GFR measurements in 20 cirrhotic patients undergoing
routine liver MRI, using a protocol that added less than 10 additional
minutes and 3 mL gadoteridol. Urinary clearance of 99mTc-DTPA served as
reference GFR. MR-GFR values were more accurate and precise than
creatinine-based GFR values. Reproducibility was comparable to the reference
method.