Abstract #0322

Short Echo Time H1 Chemical Shift Imaging Data Quantification in the Mouse Brain at 11.7T Using a Constrained Parametric Macromolecular Model

Hlne Ratiney¹, Yann Le Fur², Michal Sdika², Sophie Cavassila³

¹Universit de Lyon, CREATIS-LRMN; CNRS UMR 5220; Inserm U630; INSA-Lyon; Universit Lyon 1, Villeurbanne, France; ²Universit Aix-Marseille II, CRMBM, CNRS UMR 6612, Marseille, France; ³Universit de Lyon,, CREATIS-LRMN; CNRS UMR 5220; Inserm U630; INSA-Lyon; Universit Lyon 1, Villeurbanne, France

Short echo time chemical shift imaging (SE-CSI) data quantification at 11.7T in the mouse brain is challenging because the magnetic field inhomogeneity impact the quality of both water suppression and spectral resolution and macromolecular contamination can vary from voxel to voxel. We propose to derive from macromolecular CSI acquisition a constrained parametric macromolecular model to incorporate strong prior knowledge into the fitting of the SE-CSI. Evaluation of this approach on in vivo data acquisition is proposed and discussed.