Frank H. Miller1, Yi Wang2,
Robert McCarthy, Zongming Chen, Andrew Larson2, Laura Sternick,
Daniel Ganger, Richard Ehman3, Josh Levitsky, Reed Omary2,
Laura Merrick2, Bradley D. Bolster, Jr4, Sven
Zuehlsdorff4, Saurabh Shah4, Paul Nikolaidis2,
Vahid Yaghmai2
1Radiology , Northwestern University
Feinberg School of Medicine, Chicago, IL, United States; 2Radiology,
Northwestern University Feinberg School of Medicine, Chicago, IL, United
States; 3Radiology, Mayo Clinic; 4Siemens Healthcare
We
prospectively compared and assessed the discriminatory capabilities of MRE
and DWI in detecting and staging hepatic fibrosis in patients with suspected
chronic liver diseases using histopathologic analysis as the reference
standard. Our study demonstrated that the stiffness values on MRE had a
positive linear correlation with degree of liver fibrosis and had greater
capability for discriminating stages of fibrosis compared to ADCs on DWI.
Furthermore, the absence of fibrosis, mild fibrosis, moderate fibrosis, and
late-stage fibrosis (F3-4) can be distinguished from one to another by
stiffness values; however, the individual stages of fibrosis could not be
differentiated by ADCs.